Could CBD affect Alzheimer’s Disease, Bust Up Brain Plaque? -- Boosting PPAR-Gamma
As mentioned in earlier blogs, my background includes experience as a nurse in neurology. From this perspective one receptor holds a special interest. CBD activates receptors called PPARs [peroxisome proliferator activated receptors] that are situated on the surface of the cell’s nucleus. Like GPR55, PPARs have an effect on cancer tumors – but in this case, they have an anti-proliferative effect, effectively stifling cancer cells. PPAR receptors also regulate genes that are involved in energy homeostasis, lipid uptake, insulin sensitivity, and other metabolic functions. It stands to reason that diabetics may benefit from a CBD-rich treatment regimen.
These are all wonderful consequences of bumping up PPARs. But there’s more. PPAR activation degrades beta- amyloid, a naturally-occurring protein that, when produced in abundance, is thought to cause clusters of plaque in the brain. A long-held theory of Alzheimer’s determinant suggests that these plaque formations interrupt the communication between brain cells (neurons). Visualize brain plaque as big gluey clumps of cornstarch after it’s tossed into hot water.
For years pharmaceutical companies have tried to find a drug that would bust up brain plaque. Sadly, all of these trials have failed to benefit actual Alzheimer’s patients and there hasn’t been a new drug approved for Alzheimer’s treatment since 2002. Perhaps this vexing disease can be approached another way – If PPARs break down beta- amyloid from CBD activation could they work to stall or prevent Alzheimer’s? With an aging population worldwide, this could have enormous consequences. Time will tell.
Meredith Patterson is a nurse specializing in neurology. She writes about the brain and brain health at her blog – www.BrainStormmindfitness.com.
DISCLAIMER REGARDING SITE CONTENT AND RELATED MATERIALS
Please read these terms and conditions fully and carefully. If you do not agree to be bound to each and every term and condition set forth herein, please exit the Site and do not access, read or otherwise use information provided herein.
The blog provides only general information and discussion about medicine, health and related subjects. Any views or opinions represented in this blog are personal and belong solely to the specific author and do not represent those of people, academic, hospital, practice or other institutions or organizations that the author may or may not be associated with in professional or personal capacity, and do not represent the views or opinions of GB Sciences, Inc., unless explicitly stated.
The words and other content provided in this blog, and in any linked materials, are not intended and should not be construed as medical advice. Nothing contained in the Site is intended to establish a physician-patient relationship, to replace the services of a trained physician or health care professional, or otherwise to be a substitute for professional medical advice, diagnosis, or treatment. If the reader or any other person has a medical concern, he or she should consult with an appropriately-licensed physician or other health care worker. The information is provided by the specific author and the author makes no representations or warranties of any kind, express or implied, about the completeness, accuracy, reliability, suitability or availability with respect to the information, products, services, or related graphics contained in the blog for any purpose. Any reliance placed on such information is therefore strictly at the reader’s own risk.
This blog may contain statements that could be construed to relate to future results or events. Words such as “expects”, “intends”, “plans”, “may”, “could”, “should”, “anticipates”, “likely”, “believes” and words of similar import may identify forward-looking statements. These statements are not historical facts, but instead represent only the specific author’s belief regarding future events, many of which, by their nature, are inherently uncertain and outside of the specific author’s control. The specific author’s beliefs are not the beliefs of GB Sciences, Inc., and do not represent the views or opinions of GB Sciences, Inc., unless explicitly stated.
It is possible that the actual results and financial condition of GB Sciences, Inc., may differ, possibly materially, from the anticipated results and financial conditions suggested in these forward-looking statements by the blog author. Information concerning the GB Sciences, Inc., and its business, including factors that potentially could materially affect GB Sciences, Inc., are contained in the company’s filings with the Securities and Exchange Commission, available at www.sec.gov. Any forward-looking statements included in this blog are made only as of the date of this blog, and neither the specific blog author nor GB Sciences, Inc., undertake any obligation to publicly update or correct any forward-looking statements to reflect events or circumstances that subsequently occur or of which they may hereafter become aware.
Through this website and blog you are able to link to other websites that are not under the control of the blog author or GB Sciences, Inc. The blog author and GB Sciences, Inc., have no control over the nature, content and availability of those sites. The inclusion of any links does not imply a recommendation or endorsement of the views and opinions expressed within them.
Content made available at the Site is provided on an “as is” and “as available” basis without warranties of any kind, either express or implied. Under no circumstances, as a result of your use of the Site, will the specific author or GB Sciences, Inc., be liable to you or to any other person for any direct, indirect, incidental, consequential, special, exemplary or other damages under any legal theory, including, without limitation, tort, contract, strict liability or otherwise, even if advised of the possibility of such damages.
By accessing the Site and/or reading its content, you acknowledge and agree that you have read and understand these terms and conditions, that the provisions, disclosures and disclaimers set forth herein are fair and reasonable, and that your agreement to follow and be bound by these terms and conditions is voluntary and is not the result of fraud, duress or undue influence exercised upon you by any person or entity.